Figure 3. Routes of Infection Determine Imaging Location.
Vaccinia virus expressing nuclear-localized green fluorescent protein was delivered to mice through intradermal, subcutaneous, or intraperitoneal injection, and the relevant areas were imaged. Vaccinia virus-infected cells are shown in green. The signal from second harmonic generation is shown in blue. Subcutanous injection in the flank results in virally infected cells in the inguinal lymph node or fat pad, while intradermal injection produces skin infection. Intraperitoneal injection results in infection of peritoneal muscle and ovaries.