FIGURE 6.

Histograms of ¹³C^α chemical shift changes in mPrP-(90–231) and two variants thereof between solutions containing, respectively, 12.9 mm DPC and no DPC. The data are plotted versus the residue numbers. At the top, the locations of the regular secondary structures in mPrP-(90–231) are indicated. Δδ(¹³C^α) is the difference between the chemical shifts of the α-carbons observed at 12.9 mm DPC and in the absence of DPC. The locations of the amino acid substitutions in the prion protein variants are indicated by asterisks. A, mPrP-(90–231); B, mPrP[P105L]-(91–231); and C, mPrP[A117V]-(90–231).