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. 2009 Jun 15;284(34):22747–22757. doi: 10.1074/jbc.M109.017806

FIGURE 10.

FIGURE 10.

The proportion of kinase rate enhancements achieved by lowering ΔH (red) and raising TΔS (cyan). ΔΔH and TΔΔS were obtained by comparing thermodynamic parameters for kinase-catalyzed phosphoryl transfer with those for spontaneous MgATP methanolysis (Table 3). For comparison, the ribosome (2, 3) and a representative single-substrate enzyme, fumarase (1), are also shown.