FIGURE 1.

Klf4 overexpression reduces neointimal hyperplasia. A, neointima hyperplasia 14 days after balloon injury. Representative sections of hemotoxylin and eosin-stained arterial section from uninjured, model, or pAd- or pAd-Klf4-infected rats. Magnification, ×200. B, morphometric data. **, p < 0.01 versus model group (n = 6 in each group). C, evaluation of VSMC proliferative index by immunohistochemical staining using anti-PCNA. The PCNA index was calculated as follows: PCNA-positive cells/total cells × 100. The bars represent the means ± S.D. of six independent experiments. *, p < 0.05 versus pAd group.