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. 2003 Nov 15;31(22):6428–6434. doi: 10.1093/nar/gkg875

Figure 4.

Figure 4

B[c]PhDE-induces MMR-dependent apoptosis. (A) TUNEL analysis. Cells were treated with 0.25 µM B[c]PhDE at 37°C for 1 h, cultured in fresh medium for various times as indicated, and subjected to TUNEL analysis as described in Materials and Methods. (B) DNA fragmentation analysis. Cells were treated with B[c]PhDE (0.25 µM) for 1 h and cultured in fresh medium for 24 h. Genomic DNA was isolated by protease K digestion and phenol/chloroform extractions, fractionated through 1.5% agarose gels and visualized under UV light in the presence of ethidium bromide.