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. 2009 Jun 25;284(34):23037–23045. doi: 10.1074/jbc.M109.033332

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Rose bengal penetrance in normal (HCjE) and neoplastic (Caco-2, ECC-1, BT-20) epithelial cells. Different cell lines of epithelial origin were incubated for 1 h with the non-competitive inhibitor of galectin binding, sucrose, and with the competitive inhibitors, β-lactose and MCP, followed by rose bengal assay. Islands of cells excluding the rose bengal were observed in all epithelial cell lines grown for 7 days after confluence. Competitive inhibition of galactose-dependent surface interactions with β-lactose or MCP significantly increased rose bengal penetrance in HCjE, Caco-2, and ECC-1 cells but not in BT-20, suggesting that the galactose-dependent response of the epithelial cultures is cell type-specific (*, p < 0.01; **, p < 0.001). Representative micrographs are shown in the lower panel.