Table 4.
Trials of supplemental vitamin D excluded from the primary analyses but included in sensitivity analyses
| Source | Reason for exclusion | Number of participants | Age (years; mean (SD)) | Sample population | Treatment (daily dose) | Adherence | Study duration (months) | 25(OH)D serum concentration (mmol/l; mean (SD)) | |
|---|---|---|---|---|---|---|---|---|---|
| Treatment group | Control group | ||||||||
| Grant et al, 2005w9 | Insufficient fall assessment | 5292 (4481 women, 811 men) | 77 (6) | Individuals who were mobile before developing a low trauma fracture | 800 IU vitamin D3 with or without 1000 mg calcium (calcium carbonate) | 47% | 24 | 38 (16) to 62 (19.5) at 12 months | 38 (16) to 45.8 (18) at 12 months |
| Trivedi et al, 2003w10 | Insufficient fall assessment | 2686 (2037 men, 649 women) | 75 (5) | Community dwelling individuals | 800 IU vitamin D3 (100 000 IU every 4 months) or placebo | 80% | 60 | 74.3 (20.7) at 48 months | 53.4 (21.1) at 48 months |
| Chapuy et al, 2002w11 | Insufficient fall assessment | 583 women | 85 (7) | Ambulatory individuals living in apartment houses for elderly persons | 800 IU vitamin D3 + 1200 mg calcium (tri-calcium phosphate) or placebo | 95% | 24 | 21.3 (13.3) to 77.5 at 24 months | 22.8 (17.3) to 15 from bar graph at 24 months |
| Kärkkäinen et al, 2007w12 | Open study design | 3432 women | 67 | Community dwelling individuals | 800 IU vitamin D3 + 1 g calcium or control group (no placebo) | Adherence not stated | 36 | Not done | Not done |
| Law 2 et al, 006w13 | Open study design | 3717 (2788 women, 929 men) | 85 | Patients living in residential accommodation | 1100 IU vitamin D2 (100 000 IU ergocalciferol every 3 months) or no treatment (no placebo) | Adherence not stated | 10 | 47 (35-102) to 74 (52-110) at 3 months | Not done |
| Harwood et al, 2004w14 | Open study design | 76 women | 82 (67-92) | Patients in rehabilitation wards, previously community dwelling | 800 IU vitamin D3 + 1 g calcium or control group (no placebo) | Adherence not stated | 12 | 30 (6-75), to 50 at 12 months | 30 (12-64), to 27 at 12 months |
| Latham et al, 2003w15 | Patients in unstable health | 243 (129 women, 114 men) | 80 (77-81) | Patients in acute care for any reason | 1600 IU vitamin D2 (300 000 IU as single dose) or placebo | 100% | 6 | 37.5 (35-45) to 60 at 3 months | 47.5 (40-52.5) to 47.5 at 3 months |