Table 2.
Trabecular 3-D microarchitectural parameters for femur and lumbar spine of mice following different cage conditions
| Parameters | Femur | Lumbar Spine | ||||||
|---|---|---|---|---|---|---|---|---|
| MIS | IVCR | IVC | SD | MIS | IVCR | IVC | SD | |
| BS/BV (mm−1)a | 136 | 155 | 137 | 11 | 128 | 130 | 129 | 1 |
| X | 140 | 160 | 144 | 11 | 139 | 140 | 150 | 6 |
| Y | 143 | 162 | 144 | 11 | 147 | 153 | 144 | 5 |
| Z | 124 | 141 | 120 | 11 | 99 | 97 | 93 | 3 |
| BV/TV (%)b | 13 | 13 | 13 | 0 | 15 | 16 | 14 | 1 |
| TbTh (μm)c | 15 | 14 | 15 | 1 | 16 | 16 | 16 | 0 |
| X | 15 | 13 | 14 | 1 | 15 | 14 | 14 | 1 |
| Y | 14 | 13 | 14 | 1 | 14 | 14 | 14 | 0 |
| Z | 17 | 15 | 17 | 1 | 21 | 20 | 22 | 1 |
| TbN (mm−1)d | 9 | 9 | 9 | 0 | 9 | 12 | 9 | 2 |
| X | 9 | 10 | 10 | 1 | 10 | 14 | 10 | 2 |
| Y | 9 | 10 | 9 | 1 | 10 | 13 | 10 | 2 |
| Z | 8 | 9 | 8 | 1 | 7 | 9 | 6 | 2 |
| TbSp (μm)e | 102 | 96 | 99 | 3 | 107 | 102 | 102 | 3 |
| X | 102 | 92 | 96 | 5 | 97 | 84 | 88 | 7 |
| Y | 98 | 92 | 94 | 3 | 94 | 93 | 91 | 2 |
| Z | 110 | 105 | 113 | 4 | 144 | 129 | 143 | 8 |
IVC control (normal area) cage group, IVCR 50% reduced area control cage group, MIS “Mice in Space” cage group, SD standard deviation
aBone surface to bone volume (BS/BV) × mm−1
bBone volume to total tissue volume (BV/TV) in percent (%)
cTrabecular thickness (TbTh) in microns (μm)
dTrabecular numbers (TbN) × mm−1
eTrabecular separation (TbSp) in microns (μm)