TABLE 3.
Inhibitor | Varied substrate | Fixed substrate | Type of inhibition | Ki | βa |
---|---|---|---|---|---|
μm | |||||
CMP | CDP-glycerol | Lipid ϕ analog | Competitive | 182 ± 35 | |
CMP | Lipid ϕ analog | CDP-glycerol | Non-competitive (partial) | 156 ± 30 | 0.23 ± 0.04 |
a β is a constant in Equation 4 that modifies the rate of product formation when inhibitor is bound to the enzyme·substrate complex (28).