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. 2009 Jun 15;284(32):21192–21200. doi: 10.1074/jbc.M109.006163

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© 2009 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 9. — Schematic model of S1P synthesis and export in platelets and erythrocytes. S1P is synthesized via the phosphorylation of sphingosine (Sph) by sphingosine kinase (SK). S1P was exported by ATP- and Ca²⁺-dependent transporters in platelets. However, thrombin-stimulated S1P export was mainly performed by the ATP-dependent transporter (21). Erythrocyte S1P transport systems do not have a Ca²⁺-dependent transporter and are not activated by any stimuli. PKC, protein kinase C; PLSCR, phospholipid scramblase.