FIGURE 8.

pICln complexes with Sm proteins and PRMT5. A, schematic illustration of pICln bound to a Sm monomer and to Sm heterooligomers. pICln is shown here interacting with the β4-surfaces of SmD3, SmD1, and SmF. B, schematic drawing of a PRMT5·pICln·Sm complex. The oligomeric state of the PRMT5 complex is likely to be at least a dimer but is illustrated here as a monomeric complex for simplicity. pICln is expected to have multiple points of contact with PRMT5, with AD3 and the PH domain regions being the most important. SmD1, SmD3, and SmB can interact with PRMT5 via their RG-tail substrates.