FIGURE 1.
Activation of α 7-5HT 3A (A and B) and human α 7 wild-type (C and D) receptors by ACh, morantel, and oxantel. A, macroscopic currents were recorded in the whole cell configuration from cells expressing α7-5HT3A chimeric receptors. Currents were elicited by 500 μm ACh, morantel, or oxantel. B, dose-response curves for ACh (●) and morantel (○) of α7-5HT3A chimeric receptors. C, macroscopic currents from human α7 in response to the application of 500 μm ACh, morantel, or oxantel in the whole cell configuration. Each trace represents the average of three to four applications of agonist. D, concentration-response curves for ACh (●) and morantel (○) of α7 AChRs. Each point is the average of three to five determinations, with the error bars representing the S.D. of the mean value. Curves are fits to the Hill equation. Membrane potential: −50 mV. The solid bar indicates the duration of the exposure to agonist (500 ms).