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Chimeric α 7–5HT 3A channels activated by ACh and anthelmintic agents. Channels activated by ACh, oxantel, or morantel at the indicated concentrations, were recorded from cells expressing the chimeric α7-5HT3A receptor. Left, traces of single-channel currents were displaced at a bandwidth of 10 kHz with channel openings as upward deflections. Right, open, closed, and burst duration histograms corresponding to each condition. Membrane potential, −70 mV.
