FIGURE 3.

Adult mammalian muscle AChRs activated by ACh, morantel, or oxantel. A, macroscopic currents were recorded from outside-out patches in response to rapid perfusion of 100 μm ACh, morantel, or oxantel. The solid bar indicates the duration of the exposure to the agonist. Membrane potential, −50 mV. B, single channels activated by 1 and 300 μm ACh, morantel, or oxantel were recorded from cells expressing adult muscle AChRs. Left, traces of currents are displaced at a bandwidth of 10 kHz with channel openings as upward deflections. Right, open and closed time histograms corresponding to each condition. Membrane potential, −70 mV.