FIGURE 6.

Docking of morantel and oxantel in α 7. Oxantel (left-hand panels: A, orientation 1; B, orientation 2; C, orientation 3) and morantel (right-hand panels: D, orientation 1; E, orientation 2; F, orientation 3) docked into a homology model of the α7 extracellular domain. The molecular structures of morantel and oxantel are shown, with colors indicating C (gray), H (white), N (blue), S (yellow), and O (red). Binding loops are colored orange (loop A), red (loop B), yellow (loop C), blue (loop D), and green (loop E). Residues Trp¹⁴⁹ and Gln⁵⁷ are depicted in red and blue, respectively.