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. 2009 May 27;284(32):21589–21598. doi: 10.1074/jbc.M109.015040

FIGURE 7.

FIGURE 7.

A subdivision of Subregion B confers bSLO3 kinetics on mSLO3 currents. A, current traces comparing the kinetics of activation of bSLO3, mSLO3, mSLO3-B chimera, and mSLO3-Bb chimera. The whole cell activation kinetics of the mSLO-B chimera and the mSLO3-Bb mutant resemble those of WT bSLO3. B, voltage dependence of the activation time constant (τact) of the same channels as in A. The bSLO3 τact and the mSLO-B and mSLO3-Bb τact are similarly voltage independent, only changing from ∼9 to 7 ms in the 0 to +80 voltage range, whereas mSLO3 τact is more voltage dependent, changing from ∼22 ms at 0 mV to 15 ms at +80 mV. mSLO3-Ba has τact values similar to mSLO3 but shows less voltage dependence with τact values ranging from 15 to 14 ms in the same voltage range.