TABLE 4.

Biological properties (cAMP stimulation) of truncation, deletion, and Ala site mutation CT receptors

Shown are EC₅₀ values for CT or small molecule ligand-stimulated intracellular cAMP responses in COS-1 cells expressing each of the noted receptor constructs, as well as E_max values reflecting maximal intracellular cAMP concentrations achieved. The basal cAMP levels in these cells were between 1.7 and 4.2 pmol/million cells. All values are the means ± S.E. of data from three independent experiments performed in duplicate.