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Time course for the development of pulmonary hypertension in male transgenic (Ren2)27 rats (Ren2 rats). Right ventricular systolic pressures (RVSPs) of Sprague-Dawley (SD) and Ren2 rats are plotted versus age (n = 2–8 rats/age group). Values are means ± SE. Solid lines indicate best-fit regressions for 7- to 13-wk-old rats; dotted lines are estimates of RVSPs in Ren2 rats.
