Effects of rosuvastatin (RSV) on pulmonary and systemic blood pressure in SD and Ren2 rats. RSV reduced RVSP (A) but not mean arterial pressure (MAP; B) in Ren2 rats. Con, control. Rats were divided into the following groups: SD control (SDC), RSV-treated SD (SDR), Ren2 control (R2C), and RSV-treated Ren2 (R2R). Significant differences were determined via ANOVA with a Tukey-Kramer post hoc test. *P < 0.05, SDC vs. R2C; §P < 0.05, SDC vs. R2R; †P < 0.05, SDR vs. R2R; ΩP < 0.05, SDR vs. R2C; ‡P < 0.05, R2C vs. R2R.