Table III.

FraX-VAS (Feelings About Self Related to Genetic Risk Information) Means (s.d) and Median.

	Carrier n = 20	Noncarrier n= 18	At-risk n = 15	p value*
Perception about how serious a problem fragile X syndrome is viewed n± S.d. [median]
How do you view fragile X, in general? 0 = very serious problem 10 = not a problem	4.9 + 3.0 [5.0]	4.96 + 3.4 [5.0]	3.5 + 2.3 [ 3.60]	0.3
Feeling about self
How has knowing your carrier status affected the way you feel about yourself (at-risk: knowing you could be a carrier)?	6.0 + 1.9 [5.1]	6.8 + 2.1 [5.7]	5.2 + 0.5 [5.0]	0.01**
Social Self
How has knowing your carrier status affected your relationship with your friends (at-risk: knowing you could be a carrier)?	6.5 + 2.0 [5.4]	6.8 + 2.1 [5.5]	4.5 + 1.8 [5.0]	0.01***
Family Self
Has knowing your carrier status affected your relationship with your parents (at-risk: knowing you could be a carrier)?	6.8 + 2.1 [5.5]	6.7 + 2.1 [5.3]	5.6 + 1.7 [5.5]	0.11
How has knowing your carrier status affected your relationship with your siblings (brothers/sisters)	6.6 + 2.0 [5.4]	6.7 + 2.4 [5.6]	5.8 + 1.6 [5.0]	0.4
How has knowing your carrier status affected your relationship with your extended family (aunts, uncles, cousins)	6.4 + 1.9 [5.5]	6.5 + 2.1 [5.1]	5.6 + 2.0 [5.0]	0.56
How has your family reacted to finding out that fragile X syndrome runs in your family?	7.2 + 2.3 [7.6]	7.1 + 2.0 [7.1]	7.4 + 1.9 [7.7]	0.92

Anchors are negative (0) to positive (10). The midpoint of 5 is intermediate indicating no effect/no difference.

^*Significance probability associated with the Kruskal-Wallis Test of the null hypothesis that there is no difference in the distribution of the outcome of interest among the three carrier status groups.

^**Data provided evidence that there were differences among the three carrier status groups with respect to the distribution of the VAS reflecting Feelings about Self. After adjustment for three pairwise multiple comparisons among the groups, the at-risk and noncarrier groups were found to differ significantly; the carrier group could not be said to differ significantly from either the noncarrier group or the at-risk group.

^***Data provided evidence that there were differences among the three carrier status groups with respect to the distribution of the VAS reflecting Social Self. The distribution of this outcome in the at-risk group was found to differ significantly from that of the other two groups after adjustment for multiple comparisons; however there was no evidence of a difference between the carrier and noncarrier groups.