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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Prostaglandins Leukot Essent Fatty Acids. 2009 May 29;81(1):53–59. doi: 10.1016/j.plefa.2009.04.008

Figure 1.

Figure 1

ARE activation by EKODE and other linoleic acid derivatives in IMR-32 cells at 10 μM using an ARE-luciferase reporter gene assay. Like tBHQ, EKODE is a strong activator of the ARE. Four other Michael acceptors (15-oxo-ETE, 13-oxo-ODE, 9-oxo-ODE, and PGJ2) exhibited weak ARE activation. ARE activation for each compound was normalized to the respective solvent (Table 1). Cotransfection of actin-lacZ served to account for differences in cell number due to effects on viability. Structures of active compounds are given. Results are the means ± standard deviation (n = 4).