. Author manuscript; available in PMC: 2010 Feb 1.

Published in final edited form as: Nat Rev Cancer. 2009 Aug;9(8):563–575. doi: 10.1038/nrc2676

Table 1. Genetically engineered mouse models of Lkb1 function in tumorigenesis.

Tissue examined	Transgenic mouse model	Phenotype	Significance	Ref
Heterozygous throughout	Lkb1+/-	Benign GI hamartomas Multi-focal osteoblastomas, paralysis	Genetic and histological phenocopy of PJS - evidence for unexpected role in bone?	¹¹⁵-⁸ ¹⁹⁵
Heterozygous throughout combined with p53 loss	Lkb1+/-, p53-/- Lkb1+/- or Lkb1+/-, p53+/-	GI hamartomas greatly accelerated hepatocellular carcinomas in one strain	p53 loss cooperates Infectious agent or strain difference?	¹⁹⁷ ¹⁹⁶
10% function thoughout	Lkb1 hypomorph	No tumor phenotype	10% LKB1 thoughout but still no tumors so unlikely polyps haploinsufficient-unless this hypomorph has compensation	137
10% function thoughout & Pten heterozygous	Lkb1 hypomorph X Pten +/-	Lymphomagenesis greatly accelerated compared to Pten +/-	In presence of reduced Pten, 10% LKB1 not enough to prevent tumorigenesis	137
GI smooth muscle cells	SM22-Cre-Lkb1^{lox/+ or lox/los}	Benign GI hamartomas	GI Polyps arising from smooth muscle - not epithelium?	119
Adult GI epithelium	Cyp2a1- Lkb1^lox/lox	Altered differentiation of Paneth and goblet cells in adult GI	Altered differentiation? Is deletion in relevant cell population for polyps?	198
Lung epithelium	Lox-Stop-Lox-Kras^G12D, Lkb1^lox/lox delivered by inhalation of adeno-Cre	Non-small cell lung cancer: aggressive lung tumors of adeno-, squamous,& large cell origin; metastasis.	LKB1 highly synergizes with K-ras mt Appearance of Squamous tumors / metastasis in adenocarcinomas	7
Endometrial epithelium	Lkb1+/- Lkb1^lox/loxintrauterine inject. of adeno-Cre	Invasive endometrial adenocarcinoma	Endometrium highly sensitive to LKB1?	121
Prostate epithelium	P450CYP1A1-Cre-Lkb1^lox/lox	Prostate hyperplasia & neoplasia	Sex-hormone regulated growth affected?	199
Skin Epithelium	Lkb1+/- with DMBA administered to skin K14-Cre-Lkb1^lox/lox with or without DMBA administered to skin	Squamous cell carcinoma of skin (and occasionally lung)	LKB1 highly synergizes with H-ras mutations induced by DMBA?	124
Pancreatic precursors	Lkb1+/- or Pdx1-Cre-Lkb1^lox/lox	Benign pancreatic cystadenomas	Altered junctions, development	200