Table 1.

Association of Met[67]Val substitution (SNP3) in Stage I.

Trait	Met[67]Val		Sample1 Dutch CVR				Sample2 Dutch FCHL			Stage I
		N=384			R2†	N=181			R2†	P‡
			β̂ *add(SE)	β̂ *dev (SE)			β̂ *add (SE)	β̂ *dev (SE)
	Val/Val	5.55±0.15				6.72±0.29
TC	Met/Val	5.20±0.07	0.19(0.9)	−0.21(0.12)	1.20%	5.90±0.17	0.28(0.11)	−0.33(0.17)§	3.64%	0.009
(mmol/L)	Met/Met	5.22±0.07				5.96±0.13
	Val/Val	3.72±0.14				4.43±0.26
LDL-C	Met/Val	3.28±0.06	0.23(0.9)	−0.30(0.12)§	2.01%	3.94±0.15	0.21(0.11)	−0.20(0.17)∥	2.03%	0.008
(mmol/L)	Met/Met	3.34±0.06				3.90±0.12
	Val/Val	1.24±0.04				1.31±0.07
ApoB	Met/Val	1.10±0.02	0.25(0.9)	−0.33(0.12)§	2.45%	1.11±0.04	0.31(0.12)	−0.32(0.17)	4.16%	0.002
(g/L)	Met/Met	1.12±0.02				1.11±0.03

Trait values represent the marginal mean evaluated at the average age and sex ±SEM.

^*β̂ _add, indicates the standardized beta coefficients per each copy of the rare allele (additive term) and β̂ _dev for the dominance-deviation term.

^†R² indicates the proportion of variance explained by the genotypic model.

^‡The p-values represent the results of the combined analysis of Sample 1 and 2, as described in Methods.

^§P < 0.05 for the significance of deviation from an additive model (^β _dev ≠ 0).

^∥P > 0.1 for the significance of deviation from an additive model.