Skip to main content
. Author manuscript; available in PMC: 2010 Apr 15.
Published in final edited form as: Structure. 2009 Apr 15;17(4):489–498. doi: 10.1016/j.str.2009.02.010

Figure 3. Small Changes in a Ligand May Modify the Binding Landscape.

Figure 3

It is not uncommon to find that small modifications in a ligand (bottom) may lead to drastic changes in the observed binding mode (bottom) (Stout et al., 1999; Badger et al., 1988; Böhm and Klebe, 1996; Kim, 2007a, 2007b; Pei et al., 2006; Reich et al., 1995; Stoll et al., 2003). This can be explained by an energy landscape with multiple minima (top), which is altered slightly by minor modifications to the ligand (top left versus top right), leading to a substantial change in the binding mode.