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. Author manuscript; available in PMC: 2009 Oct 2.
Published in final edited form as: Nat Genet. 2003 Sep 28;35(3):221–228. doi: 10.1038/ng1247

Table 1.

Mutations tested for suppression by Mvb1CAST.

Gene allele insertion element site orientation phenotypes Mechanism Suppression by Mvb1 source ref.
Pitpn vb IAP intron sense tremor, lethality decreased expression yes lab colony 1
Eya1 BOR IAP intron sense circling, deafness decreased expression yes K. Johnson 2
Agouti iy IAP intron antisense coat color; obesity ectopic expression no Jax 3
Axin Fu IAP intron antisense tailkink dominant negative no Jax 4
Dab1 scm (IAP) intron antisense ataxia splicing into parental IAP no Jax 5
Hairless hr MuLV intron sense complete hair loss decreased expression no Jax 6
Myo5a d MuLV intron sense coat color abnormal RNA expression no DBA/2J 7
Agouti a VL30 intron coat color decreased expression (isoform specific) no C57BL/6J 8

References

1

Hamilton et al. (1997) Neuron 18: 711–722

2

Johnson et al. (1999) Human Mol Genetics 8: 645–653

3

Duhl et al. (1994) Nature Genetics 8: 59–65

4

Vasicek et al. (1997) Genetics 147: 777–786

5

Ware et al. (1997) Neuron 19: 239–249; Sheldon et al. (1997) Nature 389: 730–733

6

Cachon-Gonzalez et al. (1994) Proc Natl Acad Sci USA 91: 7717–7721

7

Mercer et al. (1991) Nature 349: 709–713; Seperack et al. (1995) EMBO J. 14: 2326–2332

8

Bultman et al. (1994) Genes Dev. 8: 481–490