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. Author manuscript; available in PMC: 2009 Oct 2.
Published in final edited form as: Nat Genet. 2006 Nov 12;38(12):1446–1451. doi: 10.1038/ng1917

Figure 6. A “nucleosomal hair-trigger” model for condition-dependent transcription factor binding through coordinated interplay between local chromatin structure and DNA-binding affinity.

Figure 6

See text for details. Note that rather than the typical case of chromatin remodeling proteins acting to remove a nucleosome to effect activation, in this mechanism the enzymes act to position nucleosomes into a repressive configuration. Therefore, the default state of this system is factor binding and gene activation.