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Stimulated C-peptide responses in two insulin indepent recipients of isolated islet allografts. (A) Subject #1 displayed a significant “step-up” in portal vein C-peptide concentrations (the area shaded gray represents the excess portal vein C-peptide concentration relative to simultaneously sampled peripheral vein samples), (B) while subject #2 had nearly identical C-peptide concentrations at all time points.
