Figure 10.
NMDA receptor activation is necessary for brainstem-evoked fictive locomotion. Aa, Left and right ventral root recordings after microinjection of l-glutamate (1 mm) into the MLR. Ab, Application of the NMDA receptor antagonist d-AP5 (50 μm) to the pharmacologically isolated spinal cord abolished MLR evoked fictive locomotion. Ba, As for Figure 2, application of the 5HT1B/1D receptor agonist L694-247 (0.1 μm) slowed the ventral root bursting frequency. Bb, d-AP5 (50 μm) applied in addition to L694-247 abolished fictive locomotion.