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The histological appearances of the pin prosthesis tibiae at 6 months following gene modifications with or without particle challenges: (A) stable pin-implantation without particles stimulation; (B) Ti-particle challenged prosthesis failure control, without viral infection; (C) OPG gene transfer significantly prevented the periprosthetic membrane formation and bone resorption; while (D) Ti particle-containing prosthetic tibiae treated with AAV-LacZ.
