Table 3.

GSH-related proteins and their possible disease associations

GSH-related proteins	Disease association
Enzymes:
γ-Glutamylcysteine ligase	Hemolytic anemia, myocardial infarction, schizophrenia, neurological symptoms, COPD
Glutathione synthetase	Hemolytic anemia, metabolic acidosis, CNS dysfunction
γ-Glutamyl transpeptidase	Glutathionuria, atherosclerosis
Dipeptidase	Neurological symptoms
γ-Glutamyl cyclotransferase	(none)
5-Oxoprolinase	Neurological symptoms, hypoglycemia, kidney stones
N-Acetyltransferases	Drug sensitivity
Glutathione S-transferases	Cancer, COPD, cardiovascular disease, age-related hearing loss
Glutathione reductase	Hemolytic anemia, cardiovascular disease
Glutathione peroxidases	Osteoporosis, emphysema, cardiovascular disease
Peroxiredoxins	Hemolytic anemia, cancer, cardiovascular disease, CNS dysfunction
Glutaredoxin	Cardiovascular disease
Thioredoxin	Cardiovascular disease
Transporters:
MRP1/ABCC1	Reduced inflammatory response, multidrug resistance
MRP2/ABCC2	Dubin-Johnson syndrome
CFTR/ABCC7	Cystic fibrosis