Table 2.
Genotype distribution of IL-6 SNPs according to renal status
| SNP | Location | Genotype | CTRL | PROT/CRF/ESRD | PROT | CRF/ESRD | CTRL vs PROT/CRF/ESRD: P-value |
CTRL vs PROT: P-value |
CTRL vs CRF/ESRD: P-value |
|---|---|---|---|---|---|---|---|---|---|
| rs2069827 | 5′ flanking region | GG | 153 (90.0) | 247 (86.1) | 112 (83.0) | 135 (88.8) | 0.2564 | 0.0706 | 0.1809 |
| GT | 17 (10.0) | 37 (12.9) | 23 (17.0) | 14 (9.2) | |||||
| TT | 0 (0.0) | 3 (1.0) | 0 (0.0) | 3 (2.0) | |||||
| 170 (100.0) | 287 (100.0) | 135 (100.0) | 152 (100.0) | ||||||
| rs1800796 | 5′ flanking region | CC | 4 (2.4) | 4 (1.4) | 3 (2.2) | 1 (0.6) | 0.7344 | 0.9970 | 0.4414 |
| CG | 24 (14.1) | 43 (14.9) | 19 (14.1) | 24 (15.7) | |||||
| GG | 142 (83.5) | 241 (83.7) | 113 (83.7) | 128 (83.7) | |||||
| 170 (100.0) | 288 (100.0) | 135 (100.0) | 153 (100.0) | ||||||
| rs1800795 | 5′ flanking region | CC | 22 (13.1) | 38 (13.4) | 14 (10.6) | 24 (15.8) | 0.1535 | 0.6477 | 0.0280* |
| CG | 74 (44.1) | 100 (35.2) | 55 (41.7) | 45 (29.6) | |||||
| GG | 72 (42.9) | 146 (51.4) | 63 (47.7) | 83 (54.6) | |||||
| 168 (100.0) | 284 (100.0) | 132 (100.0) | 152 (100.0) | ||||||
| rs2069837 | Intron 2 | AA | 141 (83.4) | 232 (81.1) | 111 (82.2) | 121 (80.1) | 0.8247 | 0.9560 | 0.7455 |
| AG | 27 (16.0) | 52 (18.2) | 23 (17.0) | 29 (19.2) | |||||
| GG | 1 (0.6) | 2 (0.7) | 1 (0.7) | 1 (0.7) | |||||
| 169 (100.0) | 286 (100.0) | 135 (100.0) | 151 (100.0) | ||||||
| rs2069840 | Intron 3 | CC | 24 (14.0) | 25 (8.7) | 15 (11.2) | 10 (6.6) | 0.1266 | 0.0820 | 0.0904 |
| GC | 60 (35.1) | 120 (42.0) | 64 (47.8) | 56 (36.8) | |||||
| GG | 87 (50.9) | 141 (49.3) | 55 (41.0) | 86 (56.6) | |||||
| 171 (100.0) | 286 (100.0) | 134 (100.0) | 152 (100.0) | ||||||
| rs2069861 | 3′ lanking region | CC | 143 (84.1) | 256 (89.5) | 122 (90.4) | 134 (88.7) | 0.1487 | 0.1067 | 0.2292 |
| CT | 27 (15.9) | 29 (10.1) | 12 (8.9) | 17 (11.3) | |||||
| TT | 0 (0.0) | 1 (0.4) | 1 (0.7) | 0 (0.0) | |||||
| 170 (100.0) | 286 (100.0) | 135 (100.0) | 151 (100.0) |
*
P = 0.3360 after Bonferroni correction for 12 comparisons.
CTRL, controls; PROT, cases with proteinuria; CRF/ESRD, cases with chronic renal failure/end-stage renal disease