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. Author manuscript; available in PMC: 2010 Sep 18.

Published in final edited form as: ACS Chem Biol. 2009 Sep 18;4(9):769–781. doi: 10.1021/cb9001415

Cell survival assays. NIH-3T3 cells expressing either a TrkC (NIH-TrkC), b TrkA (NIH-TrkA), or c TrkC and p75 (nnr5-TrkC cells) were cultured in SFM supplemented with the indicated peptidomimetics (20 μM) with or without the appropriate growth factor (NGF for TrkA, NT-3 for TrkC) at optimal or suboptimal concentrations as indicated. Survival was measured in MTT assays, and was calculated relative to optimal neurotrophin (2 nM; 100% survival; 0.2 nM is therefore a suboptimal dose). Results shown are average ± SEM, from at least three independent assays, with each assay n = 4-6.

Cell survival assays. NIH-3T3 cells expressing either a TrkC (NIH-TrkC), b TrkA (NIH-TrkA), or c TrkC and p75 (nnr5-TrkC cells) were cultured in SFM supplemented with the indicated peptidomimetics (20 μM) with or without the appropriate growth factor (NGF for TrkA, NT-3 for TrkC) at optimal or suboptimal concentrations as indicated. Survival was measured in MTT assays, and was calculated relative to optimal neurotrophin (2 nM; 100% survival; 0.2 nM is therefore a suboptimal dose). Results shown are average ± SEM, from at least three independent assays, with each assay n = 4-6.