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Pharmacokinetics of AC220. (A) Time course of AC220 plasma levels in NU/NU mice after a single oral administration at 10 mg/kg. The average values from 3 independent time courses are shown in black and individual values, in red. (B) Dose dependence of AC220 peak plasma levels (Cmax) and exposure (AUC0-24 hours). The insets show a zoomed view of the data at dosages of 10 mg/kg and below. Average values from 3 independent time courses are shown in black and individual values, in red.
