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PKC-δ regulates GPVI-, but not PAR-mediated, phosphorylation of SHIP-1. Washed and indomethacin-treated murine platelets from PKC-δ−/− and age-matched WT littermates were stimulated with (A) PAR4 agonists or (B) CVX for 2 minutes. The samples were then lysed with sample buffer containing dithiothreitol (DTT) and probed for pSHIP-1 Y1020 antibody. Total Erk and β-actin were used as lane-loading controls.
