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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Toxicon. 2009 Mar 4;54(5):550–560. doi: 10.1016/j.toxicon.2008.12.027

Figure 6. Induced-fit binding of I1 to the BoNT/A active site.

Figure 6

View of the binding cleft of the BoNT/A LC (tan surface) in complex with inhibitor I1 (grey sticks). Inhibitor residues are indicated. The induced binding pockets are evidenced by the steric clashes between the apo BoNT/A LC surface (magenta) with some of the inhibitor residues (tryptophan, threonine and leucine) upon superposition (indicated by black ovals).