Table 8.

Test of nonlinearity of effects of age on regional ROIs across the age span for manual ROIs and PVEs from binary masks.

	Slope
	(cm³/year)		(cm³/year²)		R²				F (1, 196)

	Linear		Quadratic		Linear		Quadratic

ROI	Manual	PVE	Man	PVE	Man	PVE	Man	PVE	Manual	PVE
ACG	−0.002	−0.003	−0.00005	−0.00003	0.026	0.438	0.030	0.448	< 1	3.55
DLPFC	−0.115	−0.002	0.00014	−0.000002	0.400	0.527	0.401	0.527	< 1	< 1
FG	−0.055	−0.002	−0.00113	−0.00001	0.186	0.331	0.206	0.332	4.77^*	< 1
FW	−0.143	−0.00045	−0.00327	−0.00004	0.153	0.042	0.173	0.127	4.67^*	19.04^**
HC	−0.024	−0.001	−0.00177	−0.00002	0.216	0.311	0.270	0.341	14.59^**	8.99^**
IP	−0.007	−0.003	−0.00037	−0.00001	0.001	0.599	0.002	0.603	< 1	2.03
IPW	0.019	−0.00037	−0.00068	−0.00004	0.013	0.019	0.016	0.071	< 1	10.83^**
IT	−0.031	−0.001	0.00021	0.00001	0.108	0.201	0.109	0.203	< 1	< 1
MC	−0.060	−0.003	0.00039	0.000002	0.222	0.652	0.225	0.652	< 1	< 1
MCW	−0.030	0.001	−0.00091	−0.00003	0.060	0.056	0.074	0.084	2.96	6.00^*
OFC	−0.035	−0.002	0.00035	0.00001	0.243	0.418	0.249	0.424	1.52	1.81
PHG	−0.016	−0.002	−0.00028	−0.00003	0.107	0.305	0.114	0.319	1.71	3.98^*
SSC	−0.049	−0.003	0.00081	−0.00002	0.218	0.625	0.232	0.634	3.57	4.84^*
SSCW	−0.022	0.001	0.00019	−0.00002	0.050	0.052	0.051	0.069	< 1	3.70
VC	−0.013	−0.002	−0.00020	−0.00002	0.043	0.415	0.046	0.420	< 1	1.69

Note. Man = manual, PVE = partial volume estimate. Linear slope indicates estimate of rate of change in volume (cm³/year); quadratic slope is estimate of acceleration in volume (cm³/year²).

At (1, 196) df, F = 3.89 for p = 0.05;

^**

F = 6.76, p = 0.01. See Table 2 for ROI abbreviations.