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Plot on logarithmic axes of nonsynonymous nucleotide diversity (πN) vs. synonymous nucleotide diversity (πS) in (A) 76 DNA virus datasets; and (B) 146 RNA virus data sets. In each case, the line is the linear regression of log πN on log πS: for DNA viruses, log πN = -2.15 + 0.788 log πS (equivalently, πN = 0.166 πS 0.788), R2 = 59.2%; P < 0.001); for RNA viruses, log πN = -3.58 + 0.500 log πS (equivalently, πN = 0.028 πS 0.500), R2 = 33.2%; P < 0.001).
