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. Author manuscript; available in PMC: 2010 Oct 1.
Published in final edited form as: Cancer Res. 2009 Sep 14;69(19):7507–7511. doi: 10.1158/0008-5472.CAN-09-2994

Figure 1.

Figure 1

Metformin prevents transformation of MCF10A-ER-Src cells. A, Number of cells grown in the presence or absence of 1 μM 4-hydroxy tamoxifen (TAM) with the indicated concentrations of metformin for 24 hours. B, Phase-contrast images of cells grown in the presence or absence of 0.1 mM metformin and/or TAM for 36 hours. C, Wound-healing/invasion response assay of cells grown in the presence or absence of 0.1 mM metformin and/or TAM. D, Relative number of foci, colonies in soft agar, and mammospheres in untreated or TAM-treated cells in the presence of the indicated concentration of metformin.