Fig. 4.

mRNA expression pattern of tubular markers during mouse kidney development and maturation: influence of the strain. Messenger RNA quantification of proximal (a NaPiIIa, megalin, and OAT1) and distal (b AVPR2 and α-ENaC) genes in fetal (E13.5 to E18.5, blue bars), postnatal (P1 to P28, orange bars), and adult (Ad, black bar) kidneys of C57 (n = 4) and CD-1 (n = 5) mouse strains. The mRNA expression levels were first normalized by Gapdh at every developmental stage, then adjusted to the adult level set at 100%. Significant differences (P < 0.05) between the relative abundance of AQP genes in C57 and CD-1 kidneys are indicated for the appropriate time points