Table 3.
Urinary parameters in adult CD-1 and C57 mice: effect of water deprivation
| C57 | CD-1 | P value | |
|---|---|---|---|
| Baseline | |||
| Body weight (g) | 27.4 ± 0.8 | 41.3 ± 1.6 | <0.0001 |
| Kidney weight (mg/g body weight) | 7.2 ± 0.2 | 8.3 ± 0.1 | 0.003 |
| Water intake (ml/12 h) | 2.97 ± 0.75 | 6.57 ± 1.4 | <0.05 |
| Urine volume (µl/12 h) | 1402 ± 285 | 3585 ± 995 | 0.03 |
| Urine volume (µl/12 h/g BW) | 50.9 ± 9.6 | 89.2 ± 27 | NS |
| Urine osmolality (mOsmol/kgH2O) | 2470 ± 332 | 2017 ± 340 | NS |
| Urine creatinine (μg/12 h/g BW) | 25.8 ± 4.2 | 27.7 ± 3.6 | NS |
| Water deprivation | |||
| Urine volume (µl/24 h/g BW) | 20.7 ± 2.9 | 28.8 ± 3.2 | NS |
| Urine osmolality (mOsmol/kgH2O) | 3355 ± 201 | 3541 ± 52 | NS |
Data are expressed as means ± SEM, obtained on six pairs of age-matched adult males. Baseline data were obtained overnight in metabolic cages; water deprivation was performed over 24 h
NS not significant, BW body weight