Table 1.
Conserved modules are enriched for markers of major cell classes
| Network | Module | Color | Oligodendrocytes1 | Oligodendrocytes2 | Astrocytes1 | Astrocytes2 | Neurons1 | Neurons2 |
|---|---|---|---|---|---|---|---|---|
| CTX | M9A | turquoise | 138/352 P = 8.1 × 10−71 |
47/60 P = 8.3 × 10−43 |
NS | NS | NS | NS |
| CTX_95 | M9B | turquoise | 63/256 P = 4.3 × 10−37 |
29/55 P = 1.1 × 10−27 |
NS | NS | NS | NS |
| CN | M9C | turquoise | 93/352 P = 8.8 × 10−66 |
29/60 P = 2.1 × 10−28 |
NS | NS | NS | NS |
| CB | M9D | turquoise | 58/352 P = 5.6 × 10−38 |
30/60 P = 2.2 × 10−35 |
NS | NS | NS | NS |
| CTX | M15A | brown | NS | NS | 220/554 P = 2.0 × 10−122 |
19/32 P = 5.7 × 10−14 |
NS | NS |
| CTX_95 | M15B | brown | NS | 11/55 P = 3.2 × 10−3 |
145/430 P = 5.3 × 10−79 |
13/27 P = 7.2 × 10−9 |
NS | NS |
| CN | M15C | brown | NS | NS | 99/554 P = 2.5 × 10−61 |
14/32 P = 6.6 × 10−14 |
NS | NS |
| CB | M15D | brown | NS | 9/60 P = 1.0 × 10−4 |
102/554 P = 6.1 × 10−69 |
16/32 P = 1.1 × 10−17 |
NS | NS |
| CTX | M16A | blue | NS | NS | NS | NS | 164/709 P = 8.4 × 10−30 |
14/50 P = 2.0 × 10−3 |
| CTX_95 | M16B | blue | NS | NS | NS | NS | 68/546 P = 4.0 × 10−15 |
7/40 P = 2.4 × 10−2 |
| CN | M16C | blue | NS | NS | NS | NS | 64/709 P = 1.7 × 10−14 |
11/50 P = 4.4 × 10−6 |
| CB | M16D | blue | NS | NS | NS | NS | 50/709 P = 5.4 × 10−5 |
7/50 P = 4.1 × 10−2 |
Enrichment analysis for markers of major cell classes in M9, M15 and M16 in all four networks. Fractions represent the number of overlapping genes relative to the maximum possible number of overlapping genes. Data were taken from refs. 30,31 (1 and 2, respectively). Significance was assessed using Fisher’s exact text (Methods). NS, not significant.