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. Author manuscript; available in PMC: 2010 Sep 1.
Published in final edited form as: J Neuroendocrinol. 2009 Jun 12;21(9):743–752. doi: 10.1111/j.1365-2826.2009.01893.x

Figure 5. GPR30 RNAi in the mediobasal hypothalamus does not affect E2 negative feedback on LH secretion but reduces E2-induced PRL secretion.

Figure 5

OVX female rats subjected to control (shcontrol, open circle n=6) or specific GPR30 (shGPR30, filled circle, n=6) RNA interference in the mediobasal hypothalamus were injected iv with 10 μg of E2. Serial blood sample collection started 5 min before drug injection (T=0). Plasma LH (A) and PRL (B) were measured by RIA and ELISA, respectively.

In A: Two way ANOVA, no main effect of virus.

In B: Two way ANOVA, main effect of virus, F(df)= 5.33 (1,45), P<0.05

* P<0.05 versus shcontrol