Table 2.

Association between continuous AQUA scores and breast cancer–specific survival by Cox univariate analysis with 10 year follow-up

Univariate Cox Proportional Hazard Models
		95% Confidence Intervals
Variables	Risk Ratio	Lower	Upper	Effect (Chi-Square)	p-value
AQUA-ER	0.989	0.980	0.997	6.686	0.010
AQUA-PR	0.986	0.975	0.995	9.178	0.002
AQUA-EGFR	1.009	0.999	1.018	3.408	0.065
AQUA-HER-2	1.017	1.008	1.026	10.959	0.001
AQUA-HER-3	1.016	1.006	1.026	9.076	0.003
AQUA-HER-4	1.000	0.985	1.013	0.002	0.969
Age at Diagnosis	0.998	0.988	1.009	0.087	0.768
Tumor Stage				41.307	0.000
[T2 v. T1]	2.080	1.519	2.865
[T3 v. T2]	1.593	1.055	2.347
[T4 v. T3]	0.844	0.471	1.469
Nodal Stage				60.145	0.000
[pN1 v. pN0]	2.262	1.623	3.146
[pN2 v. pN1]	1.273	0.872	1.843
[pN3 v. pN2]	1.314	0.855	2.007
Distant Metastasis				28.735	0.000
[M1 v. M0]	4.646	2.837	7.185
Nuclear Grade				14.683	0.001
[2 v. 1]	1.214	0.834	1.813
[3 v. 2]	1.626	1.211	2.175