Table 3.

Association between multivariate Cox survival models and breast cancer–specific survival with 10 year follow-up (A) Models of each biomarker and including Tumor (pT) and Nodal (pN) Stage (B) All ErbB biomarkers and including Tumor (pT) and Nodal (pN) Stage (C) Cluster groups from multiplexed AQUA scores with TNM staging variables.

A) Indivudual Models - Each AQUA biomarker + (pT, pN)
		95% Confidence Interval
Variables	Risk Ratio	Lower	Upper	Effect (Chi-Square)		p-value
AQUA-ER	0.987	0.978	0.996	8.132		0.004
AQUA-PR	0.985	0.974	0.995	8.543		0.003
AQUA-EGFR	1.011	1.001	1.021	4.387		0.036
AQUA-HER-2	1.017	1.007	1.026	10.540		0.001
AQUA-HER-3	1.012	1.001	1.022	4.520	0.034
AQUA-HER-4	1.006	0.988	1.021	0.478	0.489
B) All ErbB biomarkers + (pT, pN)
		95% Confidence Intervals
Variables	Risk Ratio	Lower	Upper	Effect (Chi-Square)	p-value
AQUA-EGFR	1.004	0.989	1.018	0.366	0.545
AQUA-HER-2	1.017	1.006	1.026	9.101	0.003
AQUA-HER-3	1.013	1.001	1.025	4.257	0.039
AQUA-HER-4	1.003	0.984	1.019	0.095	0.758
C) MultiplexAQUA + TNM
		95% Confidence Intervals
Variables	Risk Ratio	Lower	Upper	Effect (Chi-Square)	p-value
Cluster Group (all v. ErbB-low VI)				18.144	0.003
ER[I]	0.629	0.429	0.892
PR[II]	0.754	0.554	1.009
HER-2/HER-3[III]	1.74	1.166	2.504
EGFR/HER-3[IV]	1.383	0.996	1.88
HER-3/HER-4[V]	0.993	0.605	1.533
Tumor Stage				26.686	>0.001
[T2 v. T1]	2.072	1.474	2.931
[T3 v. T2]	1.199	0.754	1.857
[T4 v. T3]	1.025	0.548	1.868
Nodal Stage				24.07	>0.001
[pN1 v. pN0]	1.743	1.199	2.529
[pN2 v. pN1]	1.264	0.819	1.926
[pN3 v. pN2]	1.249	0.763	2.036
Distant Metastasis				12.276	>0.001
[M1 v. M0]	3.447	1.801	6.102