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. Author manuscript; available in PMC: 2010 Apr 1.
Published in final edited form as: Cancer Res. 2009 Sep 22;69(19):7721–7728. doi: 10.1158/0008-5472.CAN-09-1419

Figure 5.

Figure 5

Effect of PD0325901 on uptake of D4-FCH in HCT116 tumors and cells. (a) Normalized time versus radioactivity curves in HCT116 tumors following daily treatment for 10 days with vehicle or 25mg/kg PD0325901. Data are the mean ± SE; n = 3 mice. (b) Summary of imaging variables %ID/vox60, %ID/vox60max, and AUC. Data are mean ± SE; * P = 0.05.

(c) Intrinsic cellular effect of PD0325901 (1μM) on D4-FCH phosphocholine metabolism after treating HCT116 cells for 1 hr with D4-FCH in culture. Data are mean ± SE; n=3 ; * P = 0.03.