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. Author manuscript; available in PMC: 2010 Oct 1.

Published in final edited form as: Hippocampus. 2009 Oct;19(10):962–972. doi: 10.1002/hipo.20579

The TAM-activated CREB repressor prevented the BDNF mRNA-increasing effects of exercise, reboxetine or exercise/reboxetine in all hippocampal regions examined. (a) CA1: *Among the WT mice, those who exercised (p = .012, n = 19), received reboxetine (p = .006, n = 8), and received the combination of the two treatments (p = .004, n = 7) expressed significantly more BDNF mRNA than those that were sedentary (n = 12) [F_(3,42) = 4.48, p = .008, n = 46]. # WT mice also expressed significantly more BDNF mRNA than CREB^IR mice for each intervention, except for sedentary mice. Among the CREB^IR mice, there were no significant differences among treatments [F_(3,36) = .791, p = .507, n = 40]. (b) CA2: *Among the WT mice, those who exercised (p = .002, n = 19), received reboxetine (p = .039, n = 8), and received the combination of the two treatments (p = .001, n = 7) expressed significantly more BDNF mRNA than those that were sedentary (n = 12) [F_(3,42) = 5.26, p = .004, n = 46]. # WT mice also expressed significantly more BDNF mRNA than CREB^IR mice for each intervention, except for sedentary mice. Among the CREB^IR mice, there were no significant differences among treatments [F_(3,36) = 1.67, p = .192, n = 40]. (c) CA3: *Among the WT mice, those who exercised (p < .0001, n = 19), received reboxetine (p < .0001, n = 8), and received the combination of the two treatments (p < .0001, n = 7) expressed significantly more BDNF mRNA than those that were sedentary (n = 12) [F_(3,42) = 20.81, p < .0001, n = 46]. # WT mice also expressed significantly more BDNF mRNA than CREB^IR mice for each intervention, except for sedentary mice. Among the CREB^IR mice, there were no significant differences among treatments [F_(3,36) = 1.34, p = .276, n = 40]. (d) CA4/hilus: *Among the WT mice, those who exercised (p < .0001, n = 19), received reboxetine (p < .0001, n = 8), and received the combination of the two treatments (p < .0001, n = 7) expressed significantly more BDNF mRNA than those that were sedentary (n = 12) [F_(3,42) = 18.70, p < .0001, n = 46]. # WT mice also expressed significantly more BDNF mRNA than CREB^IR mice for each intervention, except for sedentary mice. Among the CREB^IR mice, there were no significant differences among treatments [F_(3,36) = .346, p = .792, n = 40]. (e) DG: *Among the WT mice, those who exercised (p < .0001, n = 19), received reboxetine (p < .0001, n = 8), and received the combination of the two treatments (p < .0001, n = 7) expressed significantly more BDNF mRNA than those that were sedentary (n = 12) [F_(3,42) = 32.10, p < .0001, n = 46]. # WT mice also expressed significantly more BDNF mRNA than CREB^IR mice for each intervention, except for sedentary mice. Among the CREB^IR mice, there were no significant differences among treatments [F_(3,36) = .516, p = .674, n = 40].

The TAM-activated CREB repressor prevented the BDNF mRNA-increasing effects of exercise, reboxetine or exercise/reboxetine in all hippocampal regions examined. (a) CA1: *Among the WT mice, those who exercised (p = .012, n = 19), received reboxetine (p = .006, n = 8), and received the combination of the two treatments (p = .004, n = 7) expressed significantly more BDNF mRNA than those that were sedentary (n = 12) [F_(3,42) = 4.48, p = .008, n = 46]. # WT mice also expressed significantly more BDNF mRNA than CREB^IR mice for each intervention, except for sedentary mice. Among the CREB^IR mice, there were no significant differences among treatments [F_(3,36) = .791, p = .507, n = 40]. (b) CA2: *Among the WT mice, those who exercised (p = .002, n = 19), received reboxetine (p = .039, n = 8), and received the combination of the two treatments (p = .001, n = 7) expressed significantly more BDNF mRNA than those that were sedentary (n = 12) [F_(3,42) = 5.26, p = .004, n = 46]. # WT mice also expressed significantly more BDNF mRNA than CREB^IR mice for each intervention, except for sedentary mice. Among the CREB^IR mice, there were no significant differences among treatments [F_(3,36) = 1.67, p = .192, n = 40]. (c) CA3: *Among the WT mice, those who exercised (p < .0001, n = 19), received reboxetine (p < .0001, n = 8), and received the combination of the two treatments (p < .0001, n = 7) expressed significantly more BDNF mRNA than those that were sedentary (n = 12) [F_(3,42) = 20.81, p < .0001, n = 46]. # WT mice also expressed significantly more BDNF mRNA than CREB^IR mice for each intervention, except for sedentary mice. Among the CREB^IR mice, there were no significant differences among treatments [F_(3,36) = 1.34, p = .276, n = 40]. (d) CA4/hilus: *Among the WT mice, those who exercised (p < .0001, n = 19), received reboxetine (p < .0001, n = 8), and received the combination of the two treatments (p < .0001, n = 7) expressed significantly more BDNF mRNA than those that were sedentary (n = 12) [F_(3,42) = 18.70, p < .0001, n = 46]. # WT mice also expressed significantly more BDNF mRNA than CREB^IR mice for each intervention, except for sedentary mice. Among the CREB^IR mice, there were no significant differences among treatments [F_(3,36) = .346, p = .792, n = 40]. (e) DG: *Among the WT mice, those who exercised (p < .0001, n = 19), received reboxetine (p < .0001, n = 8), and received the combination of the two treatments (p < .0001, n = 7) expressed significantly more BDNF mRNA than those that were sedentary (n = 12) [F_(3,42) = 32.10, p < .0001, n = 46]. # WT mice also expressed significantly more BDNF mRNA than CREB^IR mice for each intervention, except for sedentary mice. Among the CREB^IR mice, there were no significant differences among treatments [F_(3,36) = .516, p = .674, n = 40].