Table 1.
Hemodynamic parameters in young and aging rats measured by the Millar pressure-volume conductance catheter system
| Young | Aging | |
|---|---|---|
| HR, beats/min | 403.1±11.6 | 359.2±20.2 |
| MAP, mmHg | 109.2±3.1 | 83.6±2.0* |
| LVSP, mmHg | 133.1±6.1 | 98.4±2.3* |
| LVEDP, mmHg | 3.8±0.9 | 9.1±0.6* |
| CI, ml·min−1·100 g−1 | 13.7±1.4 | 7.6±0.7* |
| EF, % | 72.7±7.0 | 41.6±5.4* |
| SWI, mmHg·ml·100 g−1 | 4,612±590 | 1,850±198* |
| +dP/dt, mmHg/s | 9,327±556 | 5,975±204* |
| −dP/dt, mmHg/s | 7,721±546 | 4,580±298* |
| τ (Weiss), ms | 7.8±0.4 | 11.2±0.6* |
| τ (Glantz), ms | 11.5±0.4 | 15.9±0.2* |
| TPRI, mmHg·ml−1·min−1·100 g−1 | 8.2±0.5 | 11.6±1.1* |
| SV, μl | 124.3±8.8 | 87.9±7.6* |
| EDV, μl | 199.2±14.4 | 263.2±17.5* |
| Emax, mmHg/μl | 2.6±0.2 | 1.2±0.2* |
| EDPVR slope, mmHg/μl | 0.021±0.003 | 0.04±0.004* |
| Efficiency, % | 66.2±1.9 | 43.4±2.2* |
Values are means ± SE; n = 8–10 experiments. HR, heart rate; MAP, mean arterial pressure; LVSP, left ventricular (LV) systolic pressure; LVEDP, LV end-diastolic pressure; CI, cardiac index; EF, ejection fraction; SWI, stroke work index, +dP/dt and −dP/dt, maximal slope of the systolic pressure increment and diastolic pressure decrement, respectively; τ, time constant of LV pressure decay; SV, stroke volume; EDV, end-diastolic volume; Emax, maximum elastance; EDPVR, end-diastolic pressure-volume relation.
*
P < 0.05 vs. young.