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Effects of URB597 (a); AM251 followed by vehicle (circles) or URB597 (triangles; b), and anandamide (AEA; c) on MAP in normotensive rats (solid symbols) and angiotensin II–induced hypertensive rats (open symbols). Values are mean±SEM. *P<0.05 of baseline values (n=4 to 7 for each condition). Note that AM251 blocks the hypotensive effect of subsequently administered URB597 in SHR (b).
