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. Author manuscript; available in PMC: 2009 Oct 15.
Published in final edited form as: Biochem Pharmacol. 2009 Jun 21;78(8):959–965. doi: 10.1016/j.bcp.2009.06.019

Fig. 4.

Fig. 4

PCB 104-mediated impairment of endothelium-dependent aortic ring relaxation is prevented by pharmacological inhibition of CYP1A1 or PARP. Exposure of thoracic aortic rings to 10 μM PCB 104 for 4 h significantly impaired acetylcholine-induced endothelium-dependent relaxation, an effect prevented by simultaneous incubation of the rings with the CYP 1A1 inhibitor α-naphthoflavone (NP, 0.3 μM) or the PARP inhibitor PJ-34 (3 μM). Data is expressed as mean ± SEM from 6 animals; **p < 0.01 vs. untreated rings and ††p < 0.01 vs. PCB 104 treated rings.