. Author manuscript; available in PMC: 2009 Oct 4.

Published in final edited form as: Biochem Biophys Res Commun. 2009 Jul 18;387(4):646–650. doi: 10.1016/j.bbrc.2009.07.080

Table 1.

Potencies of tested compounds at inhibiting MMP-2.

Inhibitor	IC₅₀ ± SD (µM)

	10 µM ZnSO₄	1 nM ZnSO₄
PJ-34	56 ± 14	27 ± 10
5-AIQ	102 ± 34	n.d.
3-AB	1760 ± 220^*	1000 ± 200
EB-47	>3000	n.d.
o-Phenanthroline	293 ± 14	116 ± 9
Minocycline	57 ± 6	n.d.
Doxycycline	86 ± 13	93 ± 12
GM 6001	0.0018 ± 0.0002^*	0.0063 ± 0.0006

Statistically significant difference compared to any other inhibitor, P < 0.05, one-way ANOVA with Newman–Keuls post hoc test. Reaction conditions: 50 mM Tris, pH 7.6, containing 10 mM CaCl₂, 0.05% Brij-35, 10 µM ZnSO₄; 37°C. n.d., not determined.